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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SYNGAP1 All Species: 4.55
Human Site: S389 Identified Species: 11.11
UniProt: Q96PV0 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96PV0 NP_006763.2 1343 148284 S389 G G G S G G G S G G K G K G G
Chimpanzee Pan troglodytes XP_514024 1280 143851 F367 W G E H F E F F S L P P L H S
Rhesus Macaque Macaca mulatta XP_001109824 1284 140910 K359 I L P M E L Y K E F A E Y V T
Dog Lupus familis XP_538863 1173 131030 N304 W G E H F E F N N L P A V R A
Cat Felis silvestris
Mouse Mus musculus Q3UHC7 1189 131708 G320 V V T P N P K G G K G P G P M
Rat Rattus norvegicus Q9QUH6 1308 144704 S389 G G G S G G G S G G K G K G G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512503 1229 137115 G359 V V T P P N K G K A P G P M I
Chicken Gallus gallus XP_415400 1177 132324 P308 K W Y P V V S P N P G K G K S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_690883 1278 143168 G360 V L A K G G G G G G K I I N A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q8T498 1580 173511 E426 G S G S K D K E Q L P T L R I
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 46.7 94.1 85.9 N.A. 47.7 96.1 N.A. 46 48 N.A. 53.3 N.A. 27.7 N.A. N.A. N.A.
Protein Similarity: 100 63.7 94.3 86.1 N.A. 63.2 96.6 N.A. 62.4 64.1 N.A. 66.1 N.A. 44.4 N.A. N.A. N.A.
P-Site Identity: 100 6.6 0 6.6 N.A. 6.6 100 N.A. 6.6 0 N.A. 40 N.A. 20 N.A. N.A. N.A.
P-Site Similarity: 100 6.6 0 13.3 N.A. 6.6 100 N.A. 6.6 0 N.A. 40 N.A. 20 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 10 0 0 0 0 0 0 10 10 10 0 0 20 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 20 0 10 20 0 10 10 0 0 10 0 0 0 % E
% Phe: 0 0 0 0 20 0 20 10 0 10 0 0 0 0 0 % F
% Gly: 30 40 30 0 30 30 30 30 40 30 20 30 20 20 20 % G
% His: 0 0 0 20 0 0 0 0 0 0 0 0 0 10 0 % H
% Ile: 10 0 0 0 0 0 0 0 0 0 0 10 10 0 20 % I
% Lys: 10 0 0 10 10 0 30 10 10 10 30 10 20 10 0 % K
% Leu: 0 20 0 0 0 10 0 0 0 30 0 0 20 0 0 % L
% Met: 0 0 0 10 0 0 0 0 0 0 0 0 0 10 10 % M
% Asn: 0 0 0 0 10 10 0 10 20 0 0 0 0 10 0 % N
% Pro: 0 0 10 30 10 10 0 10 0 10 40 20 10 10 0 % P
% Gln: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 20 0 % R
% Ser: 0 10 0 30 0 0 10 20 10 0 0 0 0 0 20 % S
% Thr: 0 0 20 0 0 0 0 0 0 0 0 10 0 0 10 % T
% Val: 30 20 0 0 10 10 0 0 0 0 0 0 10 10 0 % V
% Trp: 20 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 10 0 0 0 10 0 0 0 0 0 10 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _